Open-source MPI solutions are a real path for clinical research networks that want full control over the identity layer. The trade-off (engineering ownership in exchange for licensing savings) cuts differently in research than in routine he
Deterministic vs Probabilistic Subject Matching for Trial Cohorts
Deterministic and probabilistic subject matching are not interchangeable, even though most procurement documents treat them as a single check box. Each works well in a different part of the trial lifecycle, and the right MPI uses both. Here
Best MPI Tools for Sponsor-Side Subject Reconciliation in 2026
Subject reconciliation on the sponsor side is the work of taking subject records from many sources (sites, ePRO platforms, labs, imaging vendors) and producing one canonical identity per subject in the sponsor's environment. Done well, it i
Top 7 Patient Matching Algorithms for Investigator Site Reconciliation
Reconciling subject records across investigator sites is where matching algorithms earn their keep. The data is dirtier than the demos suggest, the rules of thumb that work in hospital MPI work less well in trials, and the cost of a bad mat
Top 5 FHIR-Native MPI Tools for Multi-Site Trial Networks
Multi-site trial networks live or die on whether the same subject can be recognized cleanly across sites, sponsors, and CROs. The FHIR-native MPI tools that actually deliver on that bar are a short list. Here are the five worth a real evalu
The Complete Guide to FHIR Master Patient Index for Clinical Research in 2026
A master patient index in a clinical research stack does work that looks invisible until it goes wrong. Subjects enrolled at three sites end up with three different identifiers; cross-site visits become hard to reconcile; the sponsor's data
FHIR EMR: 5 Patterns for FHIR-Native EMR Design
Designing an EMR from FHIR-first principles isn't just "use FHIR instead of proprietary formats." Five patterns cover the design decisions that separate FHIR-native from FHIR-tolerant. Pattern 1: FHIR […]
FHIR Stores: Storage Backend Choices That Affect Operations
The storage backend behind a FHIR server shapes its operational characteristics more than most buyers realize. Three storage patterns dominate 2026 deployments. Pattern 1: JPA-backed relational (Postgres, MySQL). […]
FHIR Compliance: What Actually Ships Under CMS-0057-F
CMS-0057-F requires payers to expose FHIR APIs. "Compliance" is often invoked loosely; the four specific APIs and their conformance expectations set the actual bar. Patient Access API Payers […]